What is Biotin (Vitamin H)?

What does Biotin (Vitamin H) stand for?

Biotin, also known as vitamin H and coenzyme R, is a water-soluble vitamin and also belongs to the vitamin B family, B7. It is a necessary substance for the synthesis of vitamin C and an indispensable substance for the normal metabolism of fat and protein. It is a nutrient necessary to maintain the natural growth, development and normal function of the human body.

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Biotin is one of the B vitamins, also known as vitamin H, vitamin B7, coenzyme R (Coenzyme R) and so on. 

In the 1930s, when studying the growth and respiration promoting factors of yeast growth factors and rhizobia, it was discovered from the liver as a factor that can prevent hair loss and skin damage in rats induced by feeding raw egg protein. Biotin is a member of the water-soluble vitamin B group.

 

Biotin (Vitamin H) Structure

Biotin (vitamin H) refers to a parallel ring with urea and thiophene combined with a valeric acid side chain. Biotin is a B vitamin and is a water-soluble vitamin. 

Biotin is a necessary substance for the synthesis of vitamin C and an indispensable substance for the normal metabolism of fat and protein. 

Biotin is also a coenzyme of various carboxylases and acts as a CO2 carrier in the carboxylase reaction in vivo.

 

What type of substance is Biotin?

Biotin is a photosensitive substance that constitutes the photoreceptor cells, which can maintain the integrity and soundness of the epithelial tissue structure. 

Is biotin helpful in body growth?

Biotin can also enhance the body's immune response and resistance and maintain normal growth and development.

Biotin is helpful in treatment of which conditions?

Clinically, biotin is used for the treatment of arteriosclerosis, stroke, abnormal lipid metabolism, hypertension, coronary heart disease and blood circulation disorders.

Is biotin helpful in cosmetics?

In cosmetics, it can improve the circulation speed of blood in the blood vessels of the skin. In the concentration range of 0.1% to 1.0%, it is easy to mix with the oil in the formula.

It can be used in skin care vanishing cream, sports liquid, foot pain cream, shaving liquid, and shampoo. 

What are the physiological functions of Biotin?

Biotin has a variety of physiological functions. It can help the normal synthesis and metabolism of fat, glycogen and amino acids in the human body, promote the normal operation and growth of sweat glands, nerve tissue, bone marrow, male gonads, skin and hair, reduce eczema, dermatitis symptoms, prevent white hair and hair loss, help to treat baldness, relieve muscle pain, promote urea synthesis and excretion, purine synthesis and oleic acid biosynthesis. 

It is helpful to treat arteriosclerosis, stroke, abnormal lipid metabolism, hypertension, coronary heart disease and blood circulation disorders.

 

What the scarcity of biotin lead to?

Lack of biotin can cause dermatitis, eczema, atrophic glossitis, hyperesthesia, muscle pain, fatigue, anorexia and mild anemia, hair loss.

Excessive biotin is generally not too toxic, and high-dose biotin treatment of seborrheic dermatitis has not found abnormal protein metabolism or genetic errors and other metabolic abnormalities. 

What is the recommendable dose of biotin?

The recommended dosage for adults is 25 - 300 μg per day. 

Since biotin only stays in the human body for 3 to 6 hours, it must be supplemented every day.

How id biotin useful?

Biotin is a coenzyme of various enzymes in the human body, which participates in the metabolism of fatty acids and carbohydrates in the body, promotes protein synthesis. 

It also participates in the metabolism of vitamin B12, folic acid, and pantothenic acid. 

It also promotes urea synthesis and excretion.

            It helps the normal synthesis and metabolism of fat, glycogen and amino acids in the human body

2.     Promote the normal operation and growth of sweat glands, nerve tissue, bone marrow, male gonads, skin and hair, and relieve symptoms of eczema and dermatitis

3.     Prevent gray hair and hair loss, and help to treat baldness

4.     Relieve muscle pain

5.     Promote urea synthesis and excretion, purine synthesis and oleic acid biosynthesis

 Is biotin a nutrient for fatty acid synthesis?

Biotin, also known as vitamin B7, is a member of the vitamin B group. It is mainly the cofactor of various carbonic enzymes in the human body. 

It is an indispensable nutrient for fatty acid synthesis, glycogenesis, and amino acid decomposition. Energy is very important.

 

In addition, biotin has an excellent cosmetic effect and can maintain strong hair, skin and nails. It is often added to beauty products and can also be called vitamin H. H is the abbreviation of hair Haar and skin Haut in German.

 

Which foods contain biotin?

Biotin comes from a wide variety of sources, including egg yolks, beer, yeast, nuts, beans, whole grains, mushrooms, bananas, cauliflower, fish, and more.

The raw protein contains an avidin called Avidin, which inhibits the body's absorption rate.

 

What are the recommended proven efficacy (benefits) of biotin?

1. Improve hair loss (baldness)

Hair loss is a health concern for many people, related to appearance and self-confidence, and it is estimated that nearly 50% of men and women are affected by different patterns of hair loss.

 

Nutrient deficiencies are often associated with chronic telogen effluvium, androgenetic alopecia, female pattern baldness, and patchy alopecia. While biotin is good for hair growth and strong hair, one of the main symptoms of deficiency is hair loss.

 

In one case study (in a formula-fed infant deficient in biotin), supplementation with biotin relieved symptoms of perioral dermatitis and patchyhairloss caused by the deficiency.

NB The effect of biotin on improving hair loss is unknown. So far, there is no complete clinical trial to confirm that additional supplementation can prevent or treat hair loss in the absence of deficiency.

 

2. Improve BrittleNails

Brittle nail disease is a structural abnormality of the nails. The main symptoms are loss of elasticity and softness of the nails, accompanied by cracking, peeling and crushing. 

It is estimated that about 20% of the population is affected by this disease, and the incidence of women is more than men. 2 times.

 

Brittle nails are usually idiopathic (meaning the cause is unknown) and may be caused by skin or systemic disease, nutritional deficiencies, drug use, or trauma.

 

In animal medicine, biotin is often used to improve hoof defects or abnormalities in ungulates such as horses, cattle and sheep.

 

Biotin supplementation has also been found to improve brittle nails (63% to 91% of subjects reported improvement) and nail plate thickness in several human studies.

 

The underlying mechanism is related to improving the synthesis of lipid molecules required for the manufacture of nail plate keratinocytes.

Biotin might have the effect of improving brittle nail disease, but due to the small scale of the sample study, more large-scale experiments with precise design are needed to confirm

 

3. improve diabetes

Diabetes is one of the oldest diseases in human history and was first discovered in ancient Egypt 3,000 years ago.

 

The main causative factors of diabetes are related to genes and life factors, such as lack of exercise, sedentary, smoking and drinking. Among them, obesity accounts for about 55% and is the most common causative factor.

 

A small study found that people with diabetes typically have lower blood biotin concentrations than healthy people, and that supplementation helped improve fasting blood sugar levels.

 

Another double-blind controlled study (90 days in 447 diabetic patients with poor glycemic control) showed that the additional use of chromium and biotin resulted in better glycemic control (improvement of glycation) than drug treatment alone. hemoglobin and fasting blood glucose).

 

The mechanism behind it is related to factors such as biotin's promotion of glucose synthesis into fat, glucokinase secretion (promoting hepatic glucose synthesis), and triggering of insulin, so it is believed to help maintain blood sugar stability.

 The combined use of biotin and chromium can make blood sugar control more efficient, but the effect of using it alone remains to be verified.

 

4. Multiple Sclerosis

Multiple sclerosis is an autoimmune disease caused by progressive damage to the myelin sheath in the brain or spinal cord, which coats nerve fibers, affecting other parts of the body.

 

Depending on the affected area, symptoms may include numbness in the limbs, impaired vision, fatigue, slurred speech, and dizziness.

 

A preliminary small study suggests that high doses of biotin help improve clinical symptoms of multiple sclerosis (slow progression and disability).

 

Another double-blind controlled study (12 months in 154 patients with multiple sclerosis) also found that high-dose biotin (100 μg/tid) reduced disability status compared with placebo Scale score (ExpandedDisabilityStatusScale) and improved clinical impression.

 

The mechanism behind it is related to the following two properties of biotin.

 

A. Activates carboxylase, promotes myelin repair (by increasing fatty acid synthesis)

 

b. Protects axons from degeneration caused by hypoxia (by increasing neuronal energy production)

 

High-dose biotin may help improve multiple sclerosis, but more experiments are needed to confirm

 

Does biotin have any side effects?

Biotin is a very safe nutrient, safe in most cases without side effects, and studies have used ultra-high doses of 100mg to 600mg for several months with no adverse effects (due to its water-soluble properties, excess is excreted in the urine).

 

Safety Precautions (Contraindications)

Concomitant use of high doses of pantothenic acid (vitamin B5) may have a competitive effect and hinder the absorption of biotin.

 

Taking antibiotics or sulfonamide antibiotics (Sulfonamideantibacterial) will destroy the good bacteria in the intestinal tract, resulting in a decrease in the biotin synthesis rate.

 

Long-term use of antiepileptic drugs and anticonvulsants can reduce the absorption and reabsorption of biotin in the intestinal and renal tubules.

 

Is biotin deficiency common?

Because intestinal bacteria can produce biotin by themselves, deficiency is rare. Most of the deficiency occurs in patients with congenital anomalies or deficiency of biotinidase and carboxylase. Symptoms of deficiency include eczema, hair loss and conjunctivitis. .

 

Biotin for Weight Loss

A Weight loss biotin is mainly to play a certain auxiliary role. At the same time, it must be combined with some exercise to achieve better results. 

The main thing is to choose and apply some drugs that are conducive to weight loss, such as weight loss capsules or weight loss. products, etc. for conditioning treatment, but also need to cooperate with some dietary conditioning

 

How effective is biotin for weight loss?

First of all, you have to know your physique. A Weight loss biotin is mainly to play a certain auxiliary role. At the same time, it must be combined with some exercise to achieve better results.

The main thing is to choose and apply some drugs that are conducive to weight loss, such as weight loss capsules or weight loss. products, etc. for conditioning treatment, but also need to cooperate with some dietary conditioning

 

 

Conclusion

Biotin is a type of vitamin, also known as vitamin H, vitamin B7, coenzyme R and so on. Biotin is a water-soluble vitamin, which is relatively stable to heat and has little loss in general cooking. Biotin is a coenzyme of many carboxylases in the body and plays an important role in the metabolism of carbohydrates, fats, proteins and nucleic acids. Under normal circumstances, adults with a balanced diet are generally not deficient in biotin. The avidin in the raw egg white will affect the absorption of biotin. After the egg white is cooked, the avidin is destroyed, and the biotin can be reused and absorbed.

 

 About Me 

Name: Gwynneth May

Educational Qualification: MBBS, MD (Medicine) Gold Medalist

Profession: Doctor

Experience: 16 Years of Work Experience as a Medical Practitioner