What is the Effect of the 3rd dose of Chinese Inactivated Vaccine?

 

What is the effect of the third dose of Chinese inactivated vaccine?

In accordance with the unified deployment of the State Council's joint prevention and control mechanism, in order to further strengthen the immune barrier, after preliminary preparations, various localities have initiated enhanced immunization against the new coronavirus vaccine and provided "enhanced injection" services. 

Recently, there have been confirmed cases and asymptomatic infections in Xinjiang, Gansu, Inner Mongolia, Shaanxi and other places. Does the domestic inactivated vaccine have a protective effect on the new coronavirus, especially the Delta mutant strain? What is the effect of the "strengthening needle" injection? A reporter interviewed Xu Kaifeng, chief physician of the Department of Respiratory Medicine, Peking Union Medical College Hospital.

"Published Guangzhou data show that people who have been injected with domestically-made inactivated vaccines have a stronger preventive effect.

 Compared with people who have not been vaccinated, the risk of delta new crown infection for people who have been vaccinated is only 0.25 (0.09-0.68). ), that is, the risk of infection is reduced by about 75%, and the vaccine's effective rate is about 70%." Xu Kaifeng introduced that the analysis of severe or critically ill people found that severe or critical illness occurred in people who had not been vaccinated with the new crown vaccine. This shows that the domestic vaccine is not only effective against the new coronavirus (including the delta mutant), but also has a particularly outstanding effect on preventing severe illness. "For readers who are still hesitant, wait and see, and have not yet been injected with the new crown vaccine, please arrange vaccination as soon as possible. There is no contraindication to injection for most patients with chronic diseases." Xu Kaifeng said.

 

After 6 months of vaccine injection, has the antibody titer decreased? Xu Kaifeng said that although the inactivated vaccine can achieve a good positive rate and protective effect after injection, the study found that after 6 months, the antibody titer decreased significantly compared with that after injection (the positive rate dropped to 16 %-35%).

"The new crown vaccine is not once and for all, it does need a booster shot. The third shot is not a simple repetition, and the antibody response titer is high for a long time." Xu Kaifeng said, in order to discuss how to administer the third shot, Kexing Vaccine was divided into 4 groups to conduct a comparative study. It was found that about 6 months after the second injection, the antibody titer decreased significantly, but after the third dose, the antibody titer could quickly rise to a high level. In addition, 6 months after the third injection, most of them still maintained positive titer, and the positive rate of antibody was 61%~66%. "It is foreseeable that if the third dose is injected 6 months later, higher antibody titers can be obtained, and a higher positive level is expected to be maintained in the following 6 months." Xu Kaifeng said.

 

At present, the research on the third dose of vaccine is mainly carried out in the same product or products of the same technical route. Whether the third dose of new crown vaccine can adopt vaccines of different technical routes remains to be further studied.

 

"The preventive effect of the domestic inactivated COVID-19 vaccine is very accurate, and it has a protective effect of up to 70% against the delta mutant strain, and has a strong preventive effect on the risk of severe and critical illness." Xu Kaifeng finally emphasized that in addition to vaccination against the new coronavirus, In daily life, wearing masks, maintaining social distancing and paying attention to personal hygiene cannot be relaxed.

Who is pulling the head of the vaccination?

In recent days, notices have been issued in many places. People outside the jurisdiction have organized and transported the people by various means and methods to go to other places to vaccinate the new crown, and promised to give a certain amount of rewards and subsidies, which greatly affected the overall work and vaccination. Good order. (According to China Youth Net on August 24)

In some places, people are forced to vaccinate across districts, special cars are used to pick up people, money and things are delivered, and even conflicts arise in order to snatch people. It is really "unexpected, nothing impossible."

According to relevant national regulations, the localized management of vaccination is implemented for the purpose of coordinating vaccine deployment, facilitating vaccination for the masses, improving vaccination efficiency, and facilitating follow-up effect tracking. 

Cross-regional vaccination obviously destroys the order of vaccination, and it is very likely to cause chaos and risks. If there is a vaccination safety accident that endangers the lives, health and safety of the people, it will also undermine the overall situation of epidemic prevention.

Free vaccinations of the new crown vaccine for all people are an important part of the fight against the epidemic. Everyone should work step by step, arrange time, and orderly vaccinate. Why is there such a "cross-regional pulling head" plot? Behind this, of course there are tricks. Obviously, some places have done this kind of irrational thing in order to increase the vaccination rate and make the numbers look good.

In addition, some people have not been vaccinated in time due to various reasons, but now there are people who are begging to fight and still have money to collect. How does this make those who actively cooperate with the vaccination in the beginning feel? What is the credibility and seriousness of the vaccination work?

Therefore, we must not only curb this unhealthy trend immediately, but also eliminate the root cause. For acts that actually make plans to participate in the organization, publicity, transport, contact the masses for cross-regional vaccinations, and involve the distribution of money and goods, they shall be severely punished in accordance with relevant laws and regulations. More importantly, who is the organizer? What is the root reason for this? They must be rigorously held accountable.

As the saying goes, it is easy to make mistakes in chaos. The reason for the chaos of vaccination is still because of the urgency. If you are in a hurry, you can easily break principles, and you can easily get confused when you are in a hurry.

As of August 22, the country has received nearly 1.947 billion doses of the new crown vaccine, and the number of vaccinations is close to 60% of the total population, but there is still a certain distance from the goal of herd immunity. This is not only the "task" of government departments at all levels, it should be an unshirkable responsibility of everyone. On the basis of the basic principle of "informed consent and voluntariness", the realization of "everything should be done" should be the consensus and goal of everyone.

As long as more people take the initiative to vaccinate and jointly build the Great Wall of Immunity, the chaos will naturally be impossible to take advantage of, and the forces against the new crown epidemic will be more closely and stronger.

The Chinese Center for Disease Control and Prevention issued the "Technical Guidelines for Influenza Vaccination in China (2021-2022)"

At present, the global new crown pandemic is still at a high level, and the continuous emergence of new crown virus variants has brought more uncertainty to the development of the epidemic. 

The risk of overlapping epidemics of the new crown epidemic and influenza and other respiratory infectious diseases in this autumn and winter still exists, which will increase the complexity and difficulty of prevention and control. Influenza is a vaccine-preventable disease. 

In order to reduce the interference of influenza on the prevention and control of the new crown epidemic as much as possible, and to better guide China's influenza prevention and control and vaccine application work, the Chinese Center for Disease Control and Prevention organized relevant experts to prepare and issue the "China Influenza Vaccine" in a timely manner. Technical Guidelines for Vaccination (2021-2022). 

The content of this guideline mainly includes influenza etiology, epidemiology, seasonality and other characteristics, the health and economic burdens caused by influenza in different populations, influenza vaccine types and immunogenicity, efficacy, effectiveness, cost-benefit, safety, and 2021- Recommendations for vaccination in 2022. 

Based on the current global pandemic of the new crown pneumonia epidemic, the guidelines recommend the following populations as priority vaccinations: medical personnel, including clinical rescuers, public health personnel, health and quarantine personnel, etc.

Large-scale event participants and security personnel, elderly care institutions, long-term care institutions vulnerable people and employees in crowded places such as, welfare homes, people in key places, such as teachers and students in kindergartens, primary and secondary schools, detainees and staff of prison institutions, etc.

Other high-risk groups of influenza, including those aged 60 and above Of the elderly at home, children aged 6 months to 5 years, patients with chronic diseases, family members and caregivers of babies under 6 months of age, pregnant women or women who are planning to become pregnant during the flu season, etc. People who are ≥ 6 months old and have no contraindications can be vaccinated against influenza.

 

This guide is a synthesis of the latest domestic and foreign research progress of the Influenza Vaccine Working Group of the National Immunization Program Technical Working Group of the Chinese Center for Disease Control and Prevention. It is based on the "Technical Guidelines for Influenza Vaccination in China (2020-2021)" (referred to as "Guidelines for 2020").

The guidelines are updated and revised. The updated guidelines mainly include the following aspects: 

First, new research evidence has been added, especially the research results in China, including influenza disease burden, vaccine effectiveness, vaccine safety monitoring, and vaccination. Cost effectiveness, etc.

Second, update the relevant policies and measures of the National Health Commission for influenza prevention and control in the past year.

Third, update the types of influenza vaccines approved for marketing and batch distribution in China from 2021-2022

Fourth, update this year Trivalent and quadrivalent influenza vaccine components; fifth, the 2021-2022 influenza vaccination recommendations have been updated.

 

The guidelines are applicable to staff of disease prevention and control institutions at all levels involved in influenza prevention and control, vaccinators at vaccination sites, medical staff in pediatrics, internal medicine, infectious diseases and other medical institutions at all levels, and professionals in maternal and child health institutions at all levels.

 

Influenza Vaccine Group, National Immunization Program Technical Working Group, Infectious Disease Management Division, China Center for Disease Control and Prevention