The context is finally clear, where does the new coronavirus come from
Today, the press conference of South China Agricultural University sparked public opinion. They claimed to have isolated a virus with 99% sequence similarity to the new coronavirus 2019-nCoV from pangolin.
This gives very strong evidence, suggesting that pangolins
are the intermediate host of the new coronavirus, the protagonist of this
epidemic.
We use this as a fact to explore where the new coronavirus originated?
Original article first published Knowledge Planet Knowledge
Hot
Coronavirus topics# https://t.zsxq.com/ByvNBQJ.
Related Knowing Questions:
If pangolins are the intermediate
host of the new coronavirus, how might the virus come from?
1. Where is the source of the virus?
A manuscript received by the editorial office of an
international magazine on September 30 last year (2019) was the first report
that confirmed that pangolins can carry coronavirus.
The author mentioned that the Guangdong Wildlife Rescue Center obtained 21 Malayan pangolins from the Anti-Smuggling Bureau on March 24, 2019. Most pangolins are in poor health.
Although the rescue center made great efforts, 16 of them died, and most of the pangolins had lung swelling and foamy water, pulmonary fibrosis, liver and spleen in some individuals.
Swelling. Subsequently, the authors sampled 11 individuals who died, including lung, lymph, and spleen for high-throughput sequencing.
The results showed that the reading sequence of many viruses,
including Paramyxovirus (such as Sendai virus), was found in two individuals
with coronavirus sequences.
Then they compared the detected coronaviruses with existing coronaviruses, and found that the sequenced coronaviruses in pangolins are very similar to the SARS-like coronaviruses in bats.
They submitted the relevant sequence to NCBI under the code
PRJNA573298.
2. How did the coronavirus evolve?
A few days ago, a data set of a preprinted paper appeared on the influenza virus sequence sharing website (the earliest website for sharing the new coronavirus sequence).
What they did was to compare RBD, the domain
of the S protein binding receptor on 2019-nCoV, and found that the amino acid
sequence of this part was submitted by the Guangdong Wildlife Rescue Center and
sequenced from the pangolin coronavirus. The similarity of RBD sequence is 97%.
The previous paper submitted by Shi Zhengli's team from Wuhan Institute of Virology stated that the full sequence of 2019-nCoV is very similar to a bat-derived RaTG3 strain, reaching 96.2%.
But the biggest
difference is in S protein, which has a sequence similarity of 93.1% with
S-RBD.
Shi Zhengli's team, who had identified the source of SARS, published a study. The new coronavirus receptor is the same as the SARS virus. What other key information is there?
The results of these two parts indicate that the new coronavirus
that began to spread in Wuhan is likely to jump from bats to pangolins, and
viral recombination may have occurred in pangolins, using the receptor binding
domain of the S protein of the coronavirus in pangolins.
3. How did the virus spread in Wuhan?
According to the above conclusions, the path of virus transmission is relatively clear.
The Malayan pangolin seized by the Anti-Smuggling Bureau came from Southeast Asia, and the closest strain RaTG3 isolated by researcher Shi Zhengli was also from a bat cave in Yunnan.
Yunnan is close to the southwest
border, and wild animals are not restricted by national borders. Bats can fly
and pangolins can pass. So here it is possible that the contact between bats
and pangolins led to the first species crossing of the coronavirus.
The 21 pangolins seized by the Anti-Smuggling Bureau may not
be all the stolen goods at the time.
There may be other fish that slipped through the net, and these slipped fish may have been transported to the South China Seafood Market in Wuhan through a certain transportation route, and the people who carried out this batch of pangolin smuggling were probably the first batch of infected people, and took over the pangolin and carried it.
The transportation personnel
may also be relatively early patients, and patient 0 may be in the middle of
these two groups. The cluster of cases in the seafood market is the result of
the second species crossing of the virus that we learned the first time.
In other words, smuggling and transportation of pangolins may
have caused the virus to cross species for the second time, and the virus may
have the ability to spread from person to person. These populations as the
initial source of infection led to subsequent outbreaks.
However, it cannot be ruled out that when the seafood market
received the goods, the people in the seafood market were infected by
human-to-human transmission, or that the virus species crossed again here, that
is, the virus went from pangolin to market-related personnel.
Therefore, retrospective investigation of pangolin smuggling
and transportation is likely to determine the original source of infection.
4. No profit leads to no extinction
Hope all of us got the point here
Author's Bio
Name: Gwynneth May
Educational Qualification: MBBS, MD (Medicine) Gold Medalist
Profession: Doctor
Experience: 16 Years of Work Experience as a Medical Practitioner
Comments
Post a Comment