Analysis and Collation of New Coronavirus

 

Thorough Analysis and Collation of New Coronavirus

​The Wuhan novel coronavirus belongs to the genus Betacoronavirus (Betacoronavirus). The virus is a protein-encapsulated single-stranded positive-stranded RNA virus that parasites and infects higher animals (including humans). In the position of the evolutionary tree, it is adjacent to the SARS (causing "SARS" in 2002) virus and SARS-like virus group, but it does not belong to the SARS and SARS-like virus group.

Refer also: Disease X

Has coronavirus S-protein changed? 

Four of the five key amino acids that bind to the ACE2 protein in the Wuhan coronavirus S-protein have changed. 

The ability of the new structure to interact with the ACE2 protein has decreased due to the missing few hydrogen bonds, but the changed amino acids are overall It perfectly maintains the original structural conformation of the interaction between SARS virus S-protein and human ACE2 protein. 

COVID-19

The Wuhan coronavirus is through the molecular mechanism of the interaction between S-protein and human ACE2, infects human respiratory epithelial cells, and has a strong ability to infect humans. 

It is not less than SARS, and even easier to spread than SARS, but it is slightly pathogenic. Low, that is, not as quickly as SARS causes and aggravates respiratory failure, but also makes it difficult to detect.

In how much temperature a virus like coronavirus be de-activated? 

The Wuhan coronavirus has a binding free energy of -50.6kcal/mol, which has the characteristics of weak high temperature and weak ultraviolet, that is, this type of virus can be inactivated at a high temperature of 56°C for 30 minutes. 

The common ancestor of Wuhan coronavirus and SARS/SARS-like coronavirus is a virus similar to HKU9-1. Because its evolutionary neighbors and outer groups are found in various bats, it is speculated that its natural host may also be bats. 

Infecting civet cats, people eat civet cats or bamboo rats and other rodents to get the virus. Therefore, the Wuhan coronavirus is likely to have an unknown intermediate host vector in the process of transmission from bats to humans.

 

Is Wuhan's new coronavirus is a biological weapon?

For this question, we have already accepted an interview that was with Interface News. After getting the genome on January 10, we could experience conduction of a thorough analysis. 

Based on all public data and comprehensive analysis, we believe that the virus does not come from a man-made weapon.

 

The problem of laboratory leakage is more complicated. The main reason is that currently only positive results are publicly published, that is, the design of the virus that failed the experiment is not disclosed. Therefore, this also requires that the virus sequence designed by the system must be disclosed or recorded.

 

To design a virus, some proteins must come from known viruses, and the research is particularly clear, so that they can be controlled. For example, viruses have a protein responsible for binding to antibodies on the cells of the host (human in this case). 

This part must be known, which is equivalent to that the key and the lock must be known so that we can open and close when I want to open. For example, we can use the corresponding protein of the flu virus, because the flu virus already has a vaccine. 

In the future, we may release weapons and have vaccines and therapeutic antibodies to protect myself. 

The part of the new coronavirus that is responsible for binding to the receptor has changed a lot, and once it is adopted, it may be completely out of control.

 

Another argument on the Internet is that a certain laboratory in Wuhan leaked. This probability is even more unlikely. The laboratory generally conducts research on known viruses in accordance with the rules, otherwise it will not be possible to grant project funding. 

Unless the laboratory secretly modified the virus on its own, it has not been filed. Therefore, we call on the data of scientific research projects to modify the virus to be made public.

However, synthetic biology is developing rapidly now, and there is no technical obstacle to artificially synthesizing a virus or even a bacterium. 

Previously, American scholars have modified the sequence of the coronavirus, which happened to be the introduction of the site we can discover. For this reason, we also specialize in this research. We may also conduct a survey.

Tips for Preventing from the New Coronavirus

To prevent infection with the new coronavirus, what experts suggest is:

1. Try to avoid going to public places with dense crowds and poor air circulation in the near future.

 

2. If you go out, it is recommended to wear a mask and stay away from people with flu symptoms.

 

3. Pay attention to personal hygiene and wash hands frequently.

 

4. When coughing or sneezing, please completely cover your mouth and nose with tissues or cuffs or elbow bends. When there is phlegm, wrap it and discard it, and wash your hands immediately.

 

5. Pay attention to diet and keep enough sleep, eat fruits rich in vitamin C, drink plenty of water, and reduce staying up late.

 

6. The room should be opened regularly for ventilation every day, 1-2 times a day, 15-30 minutes each time (according to the temperature of the day). Keep the elderly and children warm during ventilation.

 

7. When pregnant women and children need to go to the hospital for treatment in the near future, please try to choose a special hospital for women and children with less crowds to avoid cross-infection in the largest procedure.

 

Regarding the new coronavirus, you don’t have to panic too much. You can keep abreast of the official announcements and take care of daily family protection measures. Let us jointly control and prevent the virus and spend the Spring Festival of family reunion.

 

The new COVID-19 vaccine is not that simple at all

In 2019, 2020 and 2021 the new coronavirus is quietly sweeping the world.  

Its long incubation period, rapid transmission and various symptoms have left many countries at a loss.

 

People began to look forward to a safe and effective new coronavirus vaccine can be used as the "ultimate weapon" to end this disaster!

 

Recently, good news about the development of new coronavirus vaccines are also frequent.

 

In just 5 months, 7 candidate vaccines have entered the clinical stage. This is considered "really may be the fastest vaccine developed and promoted in human history."

 

At present, the general public generally believes that a vaccine may be successfully developed in September this year.

It is these news that give a certain illusion that the development of the new crown vaccine seems to be successful soon

 

But the facts may be better than we expected. Let us be pessimistic.

Looking at the development of new coronavirus vaccine from a historical perspective the vaccine development process includes:

Basic academic research + non-human preclinical research + human clinical research + regulatory approval + mass production, this long process may take as long as 10-20 years

 

Of course, for some viruses that desperately need vaccines, this timeline will also be shortened through various means to speed up the development process.

 

However, in fact, when the AIDS vaccine was first developed, global policies were also strongly supporting it, and scientists were also confident.

 

However, in the following 30 years, AIDS vaccine candidates have entered human clinical studies more than 200 times, but they have repeatedly failed.

 

For Ebola virus, which is highly contagious and has very severe symptoms, its vaccine development took 43 years

 

In the past 50 years, the success rate of vaccines against new epidemics was only 14%

  

The current new crown vaccine is just a big step in the journey

Looking at the new coronavirus vaccine development from a practical perspective

The new coronavirus is an RNA virus. Humans have been fighting RNA viruses for decades. To be honest, they have not succeeded yet.

 

The reason is that RNA viruses are very unstable, and random high-probability mutations occur when the virus replicates, which adds great difficulty to the development of corresponding vaccines.

 

It's like when the enemy is in a war, the enemy changes its tricks from time to time, and it is something you have never seen or foreseen. Think about the chances of winning. The new crown virus may be the unpredictable enemy

  

In addition, the surface of the new coronavirus is basically covered by a substance called "oligosaccharides", which is very similar to the virus characteristics of AIDS

 

At present, a vaccine has been successfully developed against viruses covered by "oligosaccharides". Scientists believe that the possibility is really slim.

 

It’s like the enemy is equipped with a mysterious weapon, and you haven’t found a way to defeat this weapon, so how confident are you that you can defeat the enemy?

 

At present, the development progress of the new coronavirus candidate vaccine has reached the second phase of human trials at the fastest

 

There are 4 phases of human trials, of which phases 2 and 3 are testing the effectiveness of the vaccine

 

Phase 2 trials can select specific populations, but it is often necessary to expand the trial population when entering phase 3

 

When the vaccine trial population expands to hundreds of thousands, involving the elderly and children, many problems may be exposed, and the failure rate is very high.

 

Although the research and development of the new crown vaccine is progressing rapidly, it is very important to pass the phase 3 human clinical trial. This can be called a "blocker" in the successful development of the vaccine.

In short, the road to new crown vaccine development may still be very long and far away

 

How important is vaccine safety?

Professor Jiang Shibo of Virology at Fudan University once issued an article calling on scientists around the world to “do not deploy in a hurry without sufficient security guaranteed vaccines and drugs"

 

Some scientists also remind everyone not to forget the painful memories of respiratory syncytial virus (RSV) 60 years ago. After the RSV vaccine was given to children in the United States, they found that some children got pneumonia more serious than children who were not vaccinated, and even caused it.

 

In other words, not only did the vaccine fail to prevent the disease, but it also aggravated the disease, and it may even cost lives! This is absolutely unacceptable.

  

Scientists have conducted further studies on the above phenomenon and found that some special viruses infect the human body for the second time, the symptoms caused by the first infection are much more serious than those caused by the first infection.

 

In other words, a child who has received the RSV vaccine is considered to be infected for the first time, and when a child who is vaccinated is infected with RSV in life, it is even if it is the second infection, which will produce very serious and even life-threatening symptoms.

Is the new coronavirus a "special virus"? 

Scientists have found some evidence that the new coronavirus may be a "special virus", but it is still not certain, and more scientific and detailed in-depth research is needed

 

If it is true, then the rapid development of a new coronavirus vaccine is undoubtedly worse.

We cannot ignore the safety of vaccines because of the pursuit of the speed of research and development and the immense expectation of vaccines. In the end, it will only cause more severe consequences.

 

 Author's Bio

Name: Gwynneth May

Educational Qualification: MBBS, MD (Medicine) Gold Medalist

Profession: Doctor

Experience: 16 Years of Work Experience as a Medical Practitioner

About Me